Novici’s patented GRAMMR™ technology is a novel molecular evolution platform that can generate large libraries of extensively shuffled gene sequences faster and more efficiently than traditional approaches. Novici can deliver both gene and protein libraries to clients for incorporation into product development programs.
 
Novici achieves library superiority by focusing on the regions of DNA sequence diversity rather than areas of sequence identity, which allows us to evolve even highly divergent molecules. In GRAMMR™ shuffling, genes remain full-length and the chimeric genes are generated by enzymatic resolution of mismatches in heteroduplexes formed from different parental gene DNAs. For detailed information on GRAMMR™, click here.
 
The competitive advantages of GRAMMR™ include:
  • A greater variety of chimeric products from fewer rounds of shuffling
  • Very high crossover frequency and uniform crossover site distribution
  • Rapid generation of many thousands of shuffled genes in a single day
  • Works on very large genes as well as multiple gene constructs
  • Capable of shuffling even highly divergent genes
  • No gene recloning required
  • Low background of ‘junk’ sequences means improved screening efficiencies
  • Supported by custom informatics package to seamlessly manage samples and data
 
Benefits
  • Expands your access to combinatorial space at lower cost
  • Produces shuffled libraries quickly and reliably
  • High quality shuffled libraries permit greater focus of resources on downstream applications.
 
Intellectual Property - Novici holds a number of US and foreign patents covering GRAMMR™ technology